What effects do Antibiotics play within the gastrointestinal system of patients that have taken antibiotics over a period of time?

PICOTIn the population hoe does Proton Pump Inhibitors/Protonix (ABX) compared to probiotics affect Clostridium Difficille within a year.ABSTRACTWhat effects do Antibiotics play within the gastrointestinal system of patients that have taken antibiotics over a period of time? Research shows that Protonix actually causes C.Diff over a period of time due to the flushing of the gastrointestinal systems good, as well as, the bad bacteria. Clostridium difficile is an anaerobic, spore-forming, Gram-positive bacillus and in the Western Hemisphere, one of the most common health care-acquired infection. C. diff is a normal environmental organism that becomes an opportunistic pathogen when circumstances permit. (Frary, J. A. ,2015). As patient advocates, nurses can help reduce the severity of the disease, protect other patients from acquiring CDI, and play an integral role in preventing CDI. To reduce CDI severity, astute assessment of changes in bowel consistency may help ward off severe disease. Proton pump inhibitors (PPIs) are the most widely used agents for suppression of gastric acid in patients with nonerosive gastroesophageal reflux disease and erosive esophagitis. (Frary, J. A. ,2015). Can probiotics be the way out from patient’s receiving care in a facility or at home to help fight against this bacteria?ResourcesFrary, J. A. (2015). The Association Between Proton Pump Inhibitors and Clostridium Difficile Infection: Reducing Risk. MEDSURG Nursing, 4–6.Simpson, M., & Lyon, C. (2019). PURL: Do probiotics reduce C diff risk in hospitalized patients? Journal of Family Practice, 68(6), 351.