What are the “off target” effects and what might explain them?

please follow the assignment instruction, use sources that attached .Lab Assignment 6 – Drug Discovery BackgroundRead the “Discovery and development of sorafenib: a multikinase inhibitor for treatingcancer” by Wilhem et al. (2006) on the development of sorafinib.Concentrate on thesteps that led to final approval. Summarize the steps in the sorafinib discovery processand how informatics may have played a role.• Be sure to touch on AT LEAST:• How the team decided on the specific target (Raf)?• What bioinformatics approaches may have been utilized?• The strategy for compound selection• How did they confirm the target?• What are the “off target” effects and what might explain them?• What is the proposed mechanism of action?• How did they select the target indication?No more than 1 page. It can be in point form. What you want is to get a general flow ofthe process.Note:Karaman et al. (2008) “A quantitative analysis of kinase inhibitor selectivity” in NatureBiotechechnology provides useful hints to this homework. Also note that there issupplemental information for this posted in Blackboard as well.