Based on the research, which of the factors above have the greatest impact on a patient? Why?

Consider the following factors that affect chronic illness when responding to your selected topic — pain, stigma, social isolation, altered mobility, or fatigue. Based on the research, which of the factors above have the greatest impact on a patient? Why? Contrast at least two ways the factors would affect a twelve-year-old with the way they would affect a seventy-five-year-old.