Discuss Applications of Prostate Cancer Proteomics.

1: Prostate Cancer Proteomics Disease Mechanisms1.Provide a brief introduction to the cellular and molecular mechanisms involved in prostate cancer. 2.Briefly summarise and critically evaluated the articles from Table 1 (except Garrido-Rodríguez et al., 2019, Nguyen et al., 2018, Singh and Sharma, 2020, Staunton et al., 2016 and Stelloo et al., 2017 because they should critically evaluated on Subtopic 2: Proteomic Profiling of Prostate Cancer). 3.Mention Figure 2 when discussing Carbonetti et al., 2019 article. 4.Mention the major achievements in the field as well as the main areas of debate. Subtopic 2: Proteomic Profiling of Prostate Cancer 1.Provide a brief introduction to proteomic profiling of prostate cancer. 2.Briefly summarise and critically evaluated the following papers: a)Stelloo, S., Nevedomskaya, E., Kim, Y., Hoekman, L., Bleijerveld, O., Mirza, T., Wessels, L., van Weerden, W., Altelaar, A., Bergman, A. and Zwart, W., 2017. Endogenous androgen receptor proteomic profiling reveals genomic subcomplex involved in prostate tumorigenesis. Oncogene, 37(3), pp.313-322.b)Nguyen, E., Centenera, M., Moldovan, M., Das, R., Irani, S., Vincent, A., Chan, H., Horvath, L., Lynn, D., Daly, R. and Butler, L., 2018. Identification of Novel Response and Predictive Biomarkers to Hsp90 Inhibitors Through Proteomic Profiling of Patient-derived Prostate Tumor Explants. Molecular & Cellular Proteomics, 17(8), pp.1470-1486.c)Garrido-Rodríguez, M., Ortea, I., Calzado, M., Muñoz, E. and García, V., 2019. SWATH proteomic profiling of prostate cancer cells identifies NUSAP1 as a potential molecular target for Galiellalactone. Journal of Proteomics, 193, pp.217-229.d)Singh, A. and Sharma, N., 2020. Quantitative SWATH-Based Proteomic Profiling for Identification of Mechanism-Driven Diagnostic Biomarkers Conferring in the Progression of Metastatic Prostate Cancer. Frontiers in Oncology, 10.e)Staunton, L., Tonry, C., Lis, R., Finn, S., O-Leary, J., Loda, M., Bowden, M. and Pennington, S., 2016. Profiling the tumor microenvironment proteome in prostate cancer using laser capture microdissection coupled to LC-MS-A technical report. EuPA Open Proteomics, 10, pp.19-23.3.Mention Figure 3 when discussing Stelloo et al., 2017 article.4.Mention the major achievements in the field as well as the main areas of debate. Conclusion A summary of the findings, any issues identified, areas of further research.