Have clinical research studies supported conclusions drawn from animal studies and is there a current clinical consensus regarding genetic factors, epigeneticfactors, and medical interventions?

Read the following papers to prepare for discussion: Nishijima et al. (2006) Effect of vitamin B6 deficiency on glyoxylate metabolism in rats with or without glyoxylate overload, Biomed Res 27:93-8.Runyan and Gershoff (1965) The effect of vitamin B6 deficiency in rats on the metabolism of oxalic acid precursors, J Biol Chem 240:1889-1892.Search for more recent literature that is relevant to this topic, and answer the following questions with peer‐reviewed references to support your answers.Questions to be answered:1. What is the relevance of the patient’s ethnicity (genetics)?2. What is the relevance of the patient’s diet (epigenetics)?3. How do animal studies contribute to our understanding of the problem?4. Have clinical research studies supported conclusions drawn from animal studies and is there a current clinical consensus regarding genetic factors, epigeneticfactors, and medical interventions? If not, what studies are needed to resolve any controversies?5. What is the likely biochemistry underlying the development of the patient’s problem and resolution of the problem?A minimum of three references are required:1. One or more describing genetic factors that contribute to the patient’s problem.2. One or more clinical studies that test possible dietary or pharmacological interventions.3. One or more that define amino acids, other than glycine, that are likely to contribute to the development of the patient’s problem.