What evidence suggests that the of the function (protein) is relevant to thedisease indicators?
This is a Biotechnology class and this assignment is more in Bioinformatic, I need somebody that have knowledge in this topic.I only need ASAP the answers for questions, 4,5, and 6. the rest (1,2 and 3) I’ll give more extensions days. I’m past some links, but you can find information at, GeneCard, UniProt, SelfDecode, and others souses. BSC Lab 8 – Exploring the Effects of HLA-DQA1 DiseaseThe biomarker HLA-DQA1 has been identified as associated with the following disease condition:AsthmaOur goal is to identify the abnormal function of HLA-DQA1 in these specific conditions. Wewant to identify the potential aspects of the gene/protein abnormality in order to beconsidered a “good” drug target.In two pages, please cover the following points:1. The significance of the cell function (and protein, if applicable) of the conditionyou are trying to target.o Look at the cell function and how the diseased gene/protein behaves withinthe disease. What do we know about the gene/protein overall? Hint:sequence, functional domains – look at databases like GeneCards or GeneSelfDecode.2. What evidence suggests that the of the function (protein) is relevant to thedisease indicators?o What are the lines of evidence that address the causality of the disease?What kinds of data would you use to determine this? Find primary literature toback up your information that pertain to your gene/protein of interest and thedisease itself.3. What is the targeted area, ie. where the gene is expressed in the diseasedcondition, that you will examine the various aspects of the disease?o Where in the body is it expressed with respect to the disease? Is there aspecific sub-population that is susceptible to this disease? Are there otherailments that are correlated to this disease? Think age, culture,predisposition, environment etc.4. What is the evidence that the function/molecule is tractable for drug binding &activity-based screeningo What will alter the expression of this protein? Is there a requirement forconstituent expression of this protein or is it intermittently required?5. Evidence that suggests inhibitors would be tolerated by humanso If so, what interaction do they have with humans?6. Outline a bioinformatics workflow (at the level of data sources, tools, andbasic criteria) for identifying and sources of information relating to possibletreatment of this gene/proteins pertaining to the disease of choice.o What kind of tools would help you identify possible aspects of the gene thatcould be targeted for treatment.As always, cite all sources of data in your presentation.https://www.uniprot.org/uniprot/P01909https://www.genecards.org/cgi-bin/carddisp.pl?gene=HLA-DQA1https://www.genecards.org/cgi-bin/carddisp.pl?gene=HLA-DQA1&keywords=asthma&prefilter=genomic_location#genomic_locationhttps://selfdecode.com/gene/hla-dqa1/
