Describe the pathophysiological basis for this type of hypersensitivity reaction.

A 19 month old infant presents with marked leg swelling, pain, and irritability to walk within 6 hours of receiving booster vaccinations.

Past medical history:
Primary immunizations received at 6, 10, and 14 weeks of age consisting of trivalent oral polio vaccine administered by mouth, hepatitis B virus vaccine, Haemophilus vaccine and diphtheria, pertussis and tetanus vaccine. No other childhood illnesses.

Allergies:
No prior adverse reactions noted

Physical Exam:
Vitals 38.5 degree Celsius
Respiratory rate, blood pressure and Heart Rate: normal for age
Musculoskeletal: marked swelling of the right thigh with tenderness; no discernable edema of the left thigh and no generalized edema
Skin: erythema of right thigh Review the types of hypersensitivity reactions, describe what type of hypersensitivity reaction is involved in this case, and support with evidence.
According to national guidelines, what would you advise parents regarding further immunization practices?
Describe the pathophysiological basis for this type of hypersensitivity reaction. The Biologic Basis for Disease in Adults and Children, read the following chapters:

Innate Immunity: Inflammation
Adaptive Immunity
Alterations in Immunity and Inflammation
Infection
Stress and Disease
From the Internet, read:

Zóka, A., Műzes, G., Somogyi, A., Varga, T., Szémán, B., Al-Aissa, Z., Firneisz, G. (2013). Altered immune regulation in Type 1 diabetes. Clinical and Developmental Immunology, 2013 , 1–17. Retrieved from http: //www.hindawi.com/journals/jir/2013/254874/

Alterations in Immunity
Immunity
Infection, Portals of Infection/ Antimicrobial agents and Hypersensitivity Disorders